Why Choose Peaks Curative Gummies
Peaks Gummies Tadalafil (Cialis)
As fast as 15 minutes
Lasts as long as
Affected by food?
Yes, take it 1 to 2 hours after eating,
or with a low-fat meal.
Most Common Side Effects
Headache, flushing, nasal congestion,
upset stomach, vision changes
Headache, flushing, upset stomach;
less vision changes but more
Tadalafil (generic Cialis) and sildenafil (generic Viagra) are both PDE5 inhibitors and vasodilators used for the treatment of erectile dysfunction (ED).
-Both drugs only work (allow for a man to achieve an erection) when a man is sexually aroused.
-The effects of tadalafil lasts for approximately 36 hours compared to only 4 to 5 hours for sildenafil.
-Food does not affect the efficacy of tadalafil, but food may decrease the effectiveness of sildenafil if it is taken shortly after a meal.
-Tadalafil can be used once daily, at a smaller dosage, and is also effective at treating benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension (PAH).
-Dosage of tadalafil may need to be reduced in men with liver or kidney problems and the risk of interactions with other medications may be higher than with sildenafil.
How do tadalafil and sildenafil work?
Cialis is the brand name for tadalafil, and Viagra is the brand name for sildenafil. Both belong to a class of medicines known as phosphodiesterase type 5 (PDE5) inhibitors. PDE5 inhibitors work only when a man taking them is sexually aroused, as they rely on the natural release of nitric oxide (NO), a chemical only released during sexual arousal. NO in turn activates other substances to relax the smooth muscle inside the penis to allow the inflow of blood and an erection to occur. PDE5 inhibitors are similar in structure to cGMP; they competitively bind to PDE5 and inhibit cGMP hydrolysis, thus enhancing the effects of NO. This increase in cyclic GMP in the smooth muscle cells is responsible for prolonging an erection. PDE5 inhibitors lack a direct effect on corpus cavernosum smooth-muscle relaxation.
When was each drug approved to treat ED?
On March 27th, 1998, Viagra became the first oral pill, and the first PDE5 inhibitor, to be approved by the FDA to treat ED. Generic sildenafil was approved in March 2016, and released in December 2017.
Cialis was first approved to treat ED on November 21st, 2003. It was the third PDE5 inhibitor to come onto the market (after Levitra (vardenafil)). Generic tadalafil was approved in May 2018 and released in September 2018.
How long does each drug last?
Tadalafil lasts much longer than Sildenafil – 36 hours for tadalafil, compared with 4-5 hours for Sildenafil.
How quickly do Tadalafil and Sildenafil work, and can you take them with food or immediately after eating?
Tadalafil generally begins to work within 15 to 45 minutes, and it can be taken with food or immediately after a meal.
Sildenafil generally begins to work within 30 minutes, and its effect may be diminished if taken with or shortly after a meal (which may also delay how fast it works). For this reason, Sildenafil is best taken on an empty stomach or after a low-fat meal.
The effectiveness of all PDE5 inhibitors is similar; although reported effectiveness of sildenafil, at 84% is slightly higher than that of tadalafil at 81%. However, more men prefer tadalafil because of its longer duration of effect. We believe Peaks Curative gummies will make even more men prefer tadalafil due to the great taste if our gummies and the fact that they begin to work even faster than tablets or capsules.
How are tadalafil and sildenafil normally taken?
Tadalafil can be taken either on an as needed basis or daily. Generally, daily doses are smaller than as needed doses. If an initial dose of as needed tadalafil is not effective, the dose may be increased to achieve effectiveness.
The most common side effects of Tadalafil include headache and indigestion.
Sildenafil is only taken on an as needed basis, approximately 1 hour before sexual activity (although it can be taken from as few as 30 minutes to as many as 4 hours before). The dose may be increased if the initial dose is ineffective or decreased if side effects are intolerable from the initial dose. Sildenafil should only be taken once a day even though the effects wear off after approximately 4-5 hours. The main side effects of sildenafil are headache, flushing and indigestion. Rarely, color perception may be altered with sildenafil. This side effect does not happen with tadalafil.
All PDE5 inhibitors are contraindicated with nitrates. The longer duration of action of tadalafil means it is at higher risk for drug interactions, and doses may need to be reduced in men with kidney or liver disease. Tadalafil is not recommended for men who have had a heart attack or stroke within the past 6 months, with either uncontrolled high blood pressure or severely low blood pressure, unstable angina, or other conditions that make sexual activity inadvisable. For more information on warnings and side effects of tadalafil, please see our page with more information about our tadalafil gummies.